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BSc-MSc Thesis and Internship Projects, Wageningen University

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Whole genome sequencing and analysis of mutation accumulation lines of A. nidulans.
The haploid filamentous ascomycete fungus A. nidulans produces both asexual (mitotic) and sexual (meiotic) spores. These spores are expected to be essentially genetically identical, because during selfing of a haploid meiosis does ...
Supervisor: Ben Auxier, Fons Debets
Department: Genetics, Laboratory of
 
The predictability of antibiotic resistance evolution
Evolution is driven by both chance and necessity, which make its outcome hard to predict. Laboratory evolution experiments with micro-organisms provide a powerful means to study evolution under controlled conditions in replicate p ...
Supervisor: Mark Zwart, Arjan de Visser
Department: Genetics, Laboratory of
 
The evolution of niche construction
During evolution, new genotypes may affect the environment in various ways, including the depletion of resources and the excretion of metabolites and toxins. These new conditions may present niches to which later genotypes may ada ...
Supervisor: Arjan de Visser
Department: Genetics, Laboratory of
 
Role of bacterial interactions in the evolution of antibiotic resistance
Bacterial extracellular products affect not only the fitness of the producer itself, but may also affect the fitness of other cells in the population. We study these social effects using the antibiotic-degrading enzyme TEM-1 beta- ...
Supervisor: Marjon de Vos, Mark Zwart, Andy Farr, Arjan de Visser
Department: Genetics, Laboratory of
 
Microbial ecology of Zambian fermented products: evolution of microbial communities
Microbial ecology of Zambian fermented products: evolution of microbial communities Analogous to well-known fermented products such as yoghurt, wine, beer and sauerkraut, Zambia has many endogenous fermented products. The ferment ...
Supervisor: Sijmen Schoustra
Anneloes Groenenboom

Department: Genetics, Laboratory of
 
Experimental Evolution of a Sex Chromosome
Theory predicts that sex chromosomes begin with non-recombining blocks that accumulate sex-specific antagonistic alleles. In nature, fungi do not exist as males and female, but instead as hemaphrodites. To test the evolution of a  ...
Supervisor: Ben Auxier,Duur Aanen, Fons Debets
Department: Genetics, Laboratory of
 
Conflict and cooperation among fungal crops cultivated by termites
Termites in Africa and Asia cultivate fungi of the genus Termitomyces. The fungus is actively farmed by the termites in a monoculture garden well protected in the termite nest. Interactions between different fungal clones and betw ...
Supervisor: Margo Wisselink and Duur Aanen
Department: Genetics, Laboratory of
 
Genetics of non-self recognition in Basidiomycetes
Fungi, like all multicellular organisms, need to differentiate self from non-self. In vertebrates this is accomplished using the MHC loci, while mold fungi use highly polymorphic het loci. In our lab we are determining the process ...
Supervisor: Ben Auxier, Duur Aanen
Department: Genetics, Laboratory of
 
Functional analysis of candidate genes for sex ratio in parasitoid wasps
Can alternative splicing of candidate genes explain differential sex ratios adjustment in the genetic model parasitoid Nasonia vitripennis? In this project, you will work on the functional analysis of candidate genes for sex ra ...
Supervisor: Bart Pannebakker (GEN), Eveline Verhulst (ENT)
Department: Genetics, Laboratory of
 
Seed size variation in Lactuca
Seed size variation has been observed in Lactuca serriola/altaica populations which were recently collected in Uzbekistan. An interesting observation was that populations had long/thin seeds or short/thick seeds. From a fundamenta ...
Supervisor: Supervisor(s) Dr. Chris Kik (Centre for Genetic Resources; CGN) and Prof. dr. Bas Zwaan (Genetics)
Department: Genetics, Laboratory of
 
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